Selank

What is Selank (SK-5)?

Selank is a heptapeptide with the amino-acid sequence:

Thr-Lys-Pro-Arg-Pro-Gly-Pro

It is classified as:

• An anxiolytic peptide

• A nootropic

• A neuromodulatory peptide

In Russia, Selank has been used clinically as a non-benzodiazepine anxiolytic.

Primary Effects & Mechanisms

1. Anxiolytic (Anti-Anxiety)

Selank is best known for reducing anxiety without sedation.

Mechanisms include:

• Modulation of GABAergic signaling

• Increased expression of GABA receptors

• Reduction of stress-induced neurotransmitter imbalance

Unlike benzodiazepines:

• No physical dependence

• No cognitive dulling

• No withdrawal syndrome

2. Cognitive Enhancement (Nootropic)

Selank may improve:

• Focus and attention

• Memory consolidation

• Mental clarity under stress

This is partly due to its influence on:

• BDNF (Brain-Derived Neurotrophic Factor)

• Neuroplasticity-related gene expression