MT1

What is MT-1 (Melanotan-1)?

MT-1, commonly called Melanotan-1, is a synthetic peptide designed to mimic the action of α-melanocyte-stimulating hormone (α-MSH), a naturally occurring hormone involved in skin pigmentation.

Its primary role is to stimulate melanin production in the skin.

How MT-1 Works

MT-1 binds mainly to the melanocortin-1 receptor (MC1R) found on melanocytes (pigment-producing skin cells). When this receptor is activated:

• Melanocytes increase melanin synthesis

• Skin darkens gradually, similar to a natural tan

• Pigmentation occurs without direct UV exposure

This process is slower and more controlled compared to UV tanning.

Primary Effects and Characteristics

 Pigmentation

• Promotes eumelanin production (the darker, more UV-protective type of melanin)

• Leads to a gradual, even tan

• Often associated with fewer freckles compared to UV tanning

 Photoprotective Properties

• Increased melanin may offer some protection against UV radiation

• Originally researched for photosensitivity disorders

 Selectivity

• MT-1 is more selective for MC1R than later melanotan variants

• This selectivity contributes to fewer off-target effects compared to MT-2